2019-05-17 · The Ku70/80 heterodimer protein possesses a ring-shaped structure with high affinity for DSBs. Since this central position, the Ku70/80 dimer is a logical target for the disruption of the entire NHEJ pathway. Surprisingly, specific inhibitors of the Ku70/80 heterodimer are currently not available.

title = "The nuclear DNA repair protein Ku70/80 is a tumor-associated antigen displaying rapid receptor mediated endocytosis",. abstract = "To be of therapeutic

Here, we describe intramolecular interactions of the Ku70 C-terminal domain, known as the SAP domain. Using single-particle cryo-electron microscopy, mass spectrometric analysis of intermolecular crosslinking and molecular modelling The heterodimer, Ku70/80, is an early player in DSB repair and is part of the non-homologous end joining (NHEJ) repair pathway. Ku70/80 binds to both ends of the dsDNA at the damaged sites, acting as a marker to recruit other repair proteins required for NHEJ. The Ku70/80 complex recognizes DNA breaks and serves as an essential hub for recruitment of NHEJ components. Here, we describe intramolecular interactions of the Ku70 C‐terminal domain, known as the SAP domain.

Author links open overlay panel Takuya Abe a Masamichi Ishiai b Yoshifumi Hosono a Akari Yoshimura a Shusuke Tada a Noritaka Adachi c Hideki Koyama c Minoru Takata b Shunichi Takeda d Takemi Enomoto a e Masayuki Seki a. The yeast homologue of Ku70/80, yKu70/80, fails to bind IP 6, indicating that the function of IP 6 in non‐homologous end‐joining, like that of DNA‐PK cs, is unique to the mammalian end‐joining process. Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ku70 + Ku80 antibody (ab53126) ab53126 at 1/50 dilution staining Ku70 + Ku80 in human breast carcinoma by Immunohistochemistry, Paraffin embedded tissue in the absence and … Our previous studies indicated that the Werner syndrome protein (WRN) interacts with Ku, a heterodimeric factor of 70- and 80-kDa subunits implicated in the repair of double strand DNA breaks. Moreover, we demonstrated that Ku70/80 strongly stimulates and alters WRN exonuclease activity. A Ku70/Ku80 complex binds initially to two DNA ends at the DSB site, and then recruits a DNA‐dependent protein kinase (DNA‐PKcs), which has not been identified in plants.

Finns som: PDF Dessutom identifierade Yasui och hans grupp en Ku70 / Ku80-beroende rekrytering av DNA-ändarna av Ku70 / 80-heterodimeren som rekryterar DNA-PKcs.

Ku70/80 Drives DNA-PKcs and PARP1 to Promote CCL3 and CCL5 Expression. As mentioned earlier, the Ku70/80 complex is known for its DNA repair activities, which also require DNA-PKcs . Recently, a DNA-sensing function was reported for Ku70/80…

The Ku70/80 complex recognizes DNA breaks and serves as an essential hub for recruitment of NHEJ components. Here, we describe intramolecular interactions of the Ku70 C‐terminal domain, known as the SAP domain.

av P Umate · 2011 · Citerat av 90 — A total of 31 DNA helicases (like RecQ members, KU70, MCM DNA helicase INO80 complex homolog 1 and 2 RuvB-like helicases, Pif1,

1 Функция; 2 Старение; 3 Номенклатура; 4 Взаимодействия; 5 Примечания. Функция[править | править код]. Ku70 вместе с белком Ku80 составляют гетеродимерный Ku-бело 27 Apr 2010 The importance of the Ku70 and Ku80 proteins in DNA DSB repair after low-LET radiation is well demonstrated by the profound enhancement Ku70/80-CLU-Bax interactions. (A) Bax is localized inactive in the cytoplasm in normal, undamaged cell interacting with the Ku70 protein C-terminus.

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Monoclonal Antibody for studying Ku70 in the Cell Cycle / Checkpoint research Ku is a heterodimeric protein composed of two subunits (Ku70 and Ku80)

2008-11-01 · In addition, KU70/80 has variety of DNA-PKcs-dependent or -independent functions such as initiation of DNA replication , and telomere maintenance . However here we bring up that KU70/80 has another role in transmitting apoptosis signal as DNA-PK complex contrary to anti-apoptotic protein. Ku70/80 gene expression and DNA-dependent protein kinase (DNA-PK) activity do not correlate with double-strand break (dsb) repair capacity and cellular radiosensitivity in normal human fibroblasts. Kasten U(1), Plottner N, Johansen J, Overgaard J, Dikomey E. Ku70/80 associates with telomeric DNA ( 13) and binds to TRF1 and TRF2 ( 14, 15). Moreover, Ku has been reported to associate with hTERT and telomerase activity ( 16).

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Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double-strand break ends and is required for the non-homologous end joining (NHEJ) pathway of DNA repair.